The Swans were cruelly denied victory against Chelsea as Jose Bosingwa's deflected injury-time effort earned Chelsea a share of the spoils in front of a record attendance for the Liberty Stadium.
In what proved a hugely entertaining game, Scott Sinclair scored against his former club in the first half with a fine strike while both sides had decent chances.
The Swans were under the cosh in the second half, though Chelsea failed to create many opportunities as Michel Vorm was fairly untested.
Ashley Cole was sent off in the latter stages after he received his second booking but then, deep into four minutes of added on time, Bosingwa's cross took a heavy deflection off Neil Taylor to claim a point for the visitors.
Following the FA Cup defeat at Bolton, the Swans made another ten changes.
Ashley Williams was the sole survivor from the starting line-up that exited the FA Cup at the Reebok Stadium last weekend, with Brendan naming the same side that lost at Sunderland in the previous league game as the Swans looked to maintain their proud record.
The Swans were without loanee Josh McEachran, who was unable to feature against his parent club, as they looked to avenge the 4-1 defeat at Stamford Bridge last September.
Chelsea were without injured John Terry, former Swans loanee Frank Lampard and Ramires while Didier Drogba and Soloman Kalou were away on African Cup of Nations duty.
Swans: Michel Vorm, Angel Rangel, Steven Caulker, Ashley Williams (capt), Neil Taylor, Leon Britton, Joe Allen, Gylfi Sigurdsson (Kemy Agustien, 67), Nathan Dyer, Scott Sinclair (Luke Moore, 78), Danny Graham.
Subs: Gerhard Tremmel, Garry Monk, Jazz Richards, Wayne Routledge, Leroy Lita.
Chelsea: Petr Cech (capt), Branislav Ivanovic, Ashley Cole, David Luiz, Oriol Romeu (Michael Essien, 65), Fernando Torres, Juan Mata, Florent Malouda (Romelu Lukaku, 80), Raul Meireles, Jose Bosingwa, Daniel Sturridge.
Subs: Ross Turnbull, Paulo Ferreira, Gary Cahill, Ryan Bertrand, Lucas Piazon.
The Swans started with a high tempo, pressuring Chelsea as soon as they got hold of possession while the hosts retained the ball well in the early stages.
The first chance came after seven minutes from a set-piece. Gylfi Sigurdsson swung in a free-kick and after Steven Caulker's header was blocked, Danny Graham was denied by a fantastic block by Branislav Ivanovic.
Chelsea responded via Daniel Sturridge, who fired wide after David Luiz had ventured down the left flank before crossing low into the box.
Neil Taylor was then booked for a challenge on Sturridge before the Swans had a number of chances to take the lead. An excellent through ball from Angel Rangel sent Graham hurtling towards goal. Out came Petr Cech, but the ball squirmed back to Graham, who saw his shot kept off the line. The rebound dropped to Sinclair, but he was then denied before Allen saw his effort cleared by the back-tracking Cech.
It was thrilling stuff, and with the half-hour mark just ticking by the visitors saw Oriol Romeu volley wide from Jose Bosingwa's cross.
Nathan Dyer then saw his 20-yard effort saved by Cech before the big moment arrived. With 40 minutes on the clock, another Sigurdsson free-kick caused havoc and Graham got a slight touch before Sinclair reacted quickest to the rebound and fired into the top corner with a fine strike from 12 yards.
Ashley Cole and then Florent Malouda were booked before the break in what proved a thrilling first half
Half-time: Swans 1 Chelsea 0
The visitors applied some early pressure after the restart, but the Swans defence coped well.
Andre Villas-Boas made a change just after the hour with Michael Essien replacing Romeu, and the substitute almost made an immediate impact as he drove a thunderous shot just over the top right-hand corner.
Brendan responded by sending on Kemy Agustien for Sigurdsson as he looked to stiffen things up.
Chelsea continued to apply the pressure as the Swans were forced to defend deeply.
Another changed followed for the Swans as the game entered the last 13 minutes with Luke Moore replacing goalscorer Sinclair on the left wing.
Villas-Boas also made a switch, Romelu Lukaku coming on for Malouda as the tension levels raised at the Liberty.
The Swans still posed an attacking threat though, and Dyer went within inches of settling the game following a neat counter, but he fired just wide.
Bosingwa then saw his 20-yard drive fly just over the crossbar before the visitors saw themselves reduced to ten men for the last five minutes. Dyer outfoxed Cole and the left-back clattered the winger late and received his second booking.
There was four minutes of added on time to come though, as Chelsea threw everything forward.
And they got the goal they were looking for.
Bosingwa twisted and turned down the right, and his cross took a wicked deflection off Taylor past Michel Vorm and into the net.
It was cruel on the Swans, but they again showed that they can compete with the heavyweights of the Premier League.